This phenomenon was discovered by Stanford scientists, who discovered that the immune cells flooded
Recently, there have been a number of recent developments in the field of international medical health that continue to attract the attention of the industry and the public. For decades, scientists have generally believed that the brain's immune system is relatively independent from the body's other immune defenses. The brain has its own distinctive immune cells, and a blood-brain barrier that limits many substances and cells into brain tissue.
A new study at Stanford University challenges this view. Scientists have found that large numbers of immune cells in other parts of the human body enter the brain as humans age. This discovery may reshape scientists' awareness of the new possibilities of brain aging and its potential therapeutic implications for neurological diseases, and may eventually provide new possibilities for the treatment of neurological diseases.
This work was supported in part by a grant from the Wu Tsai Neurosciences Institute's Knights Templar Initiative for Brain Impairment and Health Impairment. This work was recently published in the journal Nature Impairment. We often think of the brain as a closed system, says Julia Belk, a postdoctoral fellow in pathology at Stanford Medical School and the first author of the new study.
The fact we found is that many immune cells actually enter the human brain during aging. She described the experience as meaningful in shaping an interdisciplinary approach that combines basic science, computer science, and medicine. This training eventually led to a collaboration with Siddhartha Jaiswal, a senior author of the new study, an associate professor of pathology at Stanford Medical School, and a member of the Institute of Stem Cell Biology and Regenerative Medicine at Stanford Medical School.
In an earlier study, researchers examined genetic information in thousands of people, including some who tracked for decades. The team showed that people carrying a cloned group of mutated immune cells were much less likely to develop Alzheimer's disease caused by mutated platelets. This result suggested the possibility that these unusual immune cells might play a role in interactions with the brain.
The researchers later found evidence that some mutant cells could enter the brain itself. The mutation involved was an undeterminate potential clonal hematopoiesis, found only in a small population. Even so, this discovery prompted the team to ask a broader question: Do immune cells regularly enter the brain from the blood as people age?
Unlike most immune cells, these immune cells are mature (mature) and divide multiple times during cell division. Compared to mature cells, immature cells divide single times during cell division. Because the number of dividing times of mature cells is finite and the number of dividing times of immature cells is infinite, the process of cell division in immature cells is much more complex than that of mature cells.
In the process of cell division in mature cells, cells divide a finite number of times during cell division, while in the process of cell division in immature cells, cells divide infinitely. It should be pointed out that the above content is based on international public research findings and is for reference in HealthCop and does not constitute clinical advice. If you have any health questions, please consult professional medical personnel.
