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Home > West Medicine > Other Specialties > Dermatology
L12.000

Bullous Pemphigoid

皮肤科

Common symptoms

疱疹、丘疹、鳞屑、发烧、黏膜损害、结痂

The pathology of disease

Bullous pemphigoid is autoimmune subepidermal blistering (anti-BP180/BP230), mostly elderly, presenting with pruritic urticarial plaques and tense bullae on flexures/extremities. Treatment: superpotent topical corticosteroids (limited disease); systemic prednisone for extensive; doxycycline; steroid-sparing agents (azathioprine/mycophenolate/methotrexate); rituximab for refractory; wound care; avoid trigger drugs (furosemide/penicillamine/ACEi/PD-1 inhibitors); follow-up.

Common Symptoms

Pruritic urticarial plaques; tense bullae; elderly; flexures

Causes and Pathogenesis

Anti-BP180/BP230 IgG causes subepidermal split and bullae.

Treatment

Topical/systemic steroids; doxycycline; steroid-sparing; rituximab

Preventive Measures

Early diagnosis; avoid trigger drugs; skin care.

Department to Visit

It is recommended to visit the Dermatology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.