Epidermolysis Bullosa Acquisita

Epidermolysis bullosa acquisita is autoimmune subepidermal blistering (anti-type-VII collagen) presenting with trauma-induced bullae/scarring/milia on hands/feet/extensor surfaces, may be associated with IBD. Treatment: systemic corticosteroids; steroid-sparing agents (dapsone/colchicine/azathioprine/cyclosporine); rituximab/IVIG for refractory; wound care; avoid trauma; treat associated IBD; follow-up.

Common Symptoms

Trauma-induced bullae; scarring/milia; hands/feet/extensors; by anti-VII collagen

Causes and Pathogenesis

Anti-type-VII collagen antibodies cause subepidermal split at anchoring fibrils.

Treatment

Steroids; steroid-sparing; rituximab; wound care; avoid trauma

Preventive Measures

Skin protection; treat IBD; wound care.

Department to Visit

It is recommended to visit the Dermatology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.