Malignant Atrophic Papulosis (Degos Disease)

Malignant atrophic papulosis (Degos disease) is characteristic 2-5 mm porcelain-white atrophic papules with erythematous telangiectatic rim on trunk/extremities, cutaneous-only benign, but systemic form has GI/CNS/mesenteric ischemia (poor prognosis). Treatment: cutaneous-only: observation; systemic: antiplatelet (aspirin/dipyridamole); anticoagulant; prostacyclin; eculizumab (emerging); treat GI perforation/CNS ischemia; monitor (endoscopy/neurologic exam); follow-up dermatology/gastroenterology/neurology; family counseling.

Common Symptoms

Porcelain-white atrophic papules; erythematous telangiectatic rim; trunk/extremities; GI/CNS risk

Causes and Pathogenesis

Endothelial injury/thrombotic vasculopathy causes atrophic papules/visceral ischemia.

Treatment

Antiplatelet/anticoagulant; eculizumab; treat GI/CNS complications; monitor

Preventive Measures

Early diagnosis; monitor visceral involvement; family counseling.

Department to Visit

It is recommended to visit the Dermatology/Gastroenterology/Neurology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.