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Home > West Medicine > Internal Medicine > Infectious Diseases
A98.300

Marburg Virus Disease

传染科

Common symptoms

昏迷、斑丘疹、背痛、嗜睡、腹泻、食欲减退、胃肠道出血、恶心、惊厥

The pathology of disease

Marburg virus disease is a newly recognized viral hemorrhagic fever in Europe; reservoir unknown. First outbreak 1967 in Europe; virus isolated.

Common Symptoms

Coma; papulomacular rash; back pain; somnolence; diarrhea; anorexia; GI bleeding; nausea; convulsion

Causes and Pathogenesis

Filoviridae; pleomorphic filamentous rods with 50-80 nm central nucleocapsid, -ssRNA. Prolonged viremia; exact pathogenesis unclear. Pathology: bleeding of skin/mucosa/soft tissue/viscera/bowel; focal necrosis worst in liver/lymphatics/testes/ovaries; scattered hepatic necrosis; small inclusions/Councilman-like bodies; glomerular fibrin thrombi; diffuse cerebral inflammation/interstitial edema.

Treatment

Drug therapy, supportive therapy

Preventive Measures

Strict patient isolation; barrier nursing; no specific treatment.

Department to Visit

It is recommended to visit the Infectious Diseases department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.