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Home > West Medicine > Internal Medicine > Hematology
百科

Polycythemia vera

血液科

Common symptoms

出血倾向、齿龈出血、疲乏、衣玉品、鼻衄、发绀、复视、鼻出血

The pathology of disease

Polycythemia vera (PV) is a clonal chronic myeloproliferative disease with erythrocytosis (plus leukocytosis/thrombocytosis); increased total blood volume, viscous blood; plethoric skin, dizziness, headache, hypertension, hepatosplenomegaly; vascular/neurologic complications, bleeding, infarction.

Common Symptoms

Bleeding tendency; gingival bleeding; fatigue; epistaxis; cyanosis; diplopia; nosebleed

Causes

Endogenous EPO-independent erythroid colonies; single clonal origin (G6PD isoenzyme A only in blood cells, A+B in fibroblasts/lymphocytes); hypersensitivity to EPO; anti-apoptosis (bcl-2 overexpression); marrow-stimulating factor.

Treatment

Drug therapy; supportive care

Prevention

Myeloproliferative disease; no clear prevention.

Recommended Department

It is recommended to visit the hematology department; before the visit you may first book an appointment and connect with experts through this platform.

Warm reminder: The above information is provided for health education reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek care at a regular hospital in time.