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Purpura fulminans is a severe thrombotic syndrome of DIC characterized by rapidly progressive skin purpura and necrosis, often following severe infection such as meningococcal sepsis; also seen in neonatal purpura fulminans from protein-C/S deficiency.
Rapidly progressive purpura; skin necrosis; fever; shock; DIC
Severe infection causes DIC with microthrombi in skin vessels, thrombosis and hemorrhagic infarction/necrosis.
Antibiotics; supportive care; replacement therapy; protein-C concentrate; debridement/amputation if needed
Early antibiotics for meningococcal disease; vaccination.
It is recommended to visit the Emergency department; an appointment can be booked on this platform before the visit.
Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.
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