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Home > West Medicine > Internal Medicine > Hematology
D80.700

Transient Infantile Hypogammaglobulinemia

血液科

Common symptoms

耳前淋巴结肿大、细菌感染、反复上呼吸道感染

The pathology of disease

Transient infantile hypogammaglobulinemia is a delayed physiologic immunoglobulin nadir in infants: transplacentally acquired maternal IgG wanes while infant IgG production starts late, causing low IgG between 3-6 months and delayed normalization up to 18-36 months. Clinical: recurrent mild infections (upper respiratory tract, otitis), no severe opportunistic infection; spontaneous recovery.

Common Symptoms

Recurrent mild upper-respiratory infection; otitis; low IgG; delayed normalization

Causes and Pathogenesis

Delayed onset of infant B-cell IgG production after maternal IgG catabolism; T/B-cell help transiently immature.

Treatment

Observation; treat infections; IVIG only if severe/recurrent

Preventive Measures

Monitor immunoglobulin levels; prevent infection; spontaneous recovery by age 4.

Department to Visit

It is recommended to visit the Pediatric Hematology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.