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Home > West Medicine > Internal Medicine > Rheumatology
M35.801

Eosinophilia-Myalgia Syndrome

风湿免疫科

Common symptoms

斑疹、嗜酸性粒细胞增多、呼吸衰竭、呼吸困难、肌痛、乏力、低热、肌肉痉挛性疼痛

The pathology of disease

Eosinophilia-myalgia syndrome (EMS) is eosinophilia + severe myalgia/skin fasciitis/polyneuropathy linked to contaminated L-tryptophan (peak 1989). Clinical: myalgia, muscle cramps, skin induration/fasciitis, paresthesias, arthritis, pulmonary HTN. Treatment: discontinue L-tryptophan/suspect agent; glucocorticoids; supportive care (pain control, PT); monitor eosinophils, CK, organ involvement; follow-up rheumatology/neurology/dermatology.

Common Symptoms

Severe myalgia; muscle cramps; skin induration; paresthesias

Causes and Pathogenesis

Toxic contaminant in L-tryptophan triggers eosinophilic tissue inflammation.

Treatment

Stop agent; glucocorticoids; supportive; monitor

Preventive Measures

Avoid suspect supplements; monitor.

Department to Visit

It is recommended to visit the Rheumatology/Neurology/Dermatology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.

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