Pyoderma Gangrenosum

Pyoderma gangrenosum is painful rapidly progressive necrolytic ulcer with undermined violaceous border on lower legs, associated with IBD/rheumatoid arthritis/hematologic malignancy/behcet. Treatment: systemic corticosteroids (prednisone); cyclosporine/tacrolimus; biologics (infliximab/adalimumab); dapsone; mycophenolate; wound care (nonadherent dressings); avoid surgical debridement (pathergy triggers worsening); treat associated systemic disease; pain management; follow-up dermatology/rheumatology/gastroenterology/hematology; monitor infection.

Common Symptoms

Painful necrolytic ulcer; undermined violaceous border; lower legs; rapidly progressive

Causes and Pathogenesis

Autoimmune neutrophilic dermatosis (pathergy) causes ulceration.

Treatment

Systemic steroids/cyclosporine/biologics; wound care; treat associated disease

Preventive Measures

Avoid trauma/surgery; treat IBD/arthritis/hematologic disease.

Department to Visit

It is recommended to visit the Dermatology/Rheumatology/Gastroenterology department; an appointment can be booked on this platform before the visit.

Warm reminder: The above information is for health science reference only and cannot replace professional medical diagnosis. If you have related symptoms, please seek medical attention at a regular hospital promptly.