The progression of bone loss, flattened microstructural malformations and mechanical damage associat

An international medical study has produced new findings that are of important reference value for disease prevention. The study is designed to describe the time-space process of aging bone loss, osteoarthritis and mechanical damage to establish a time-space evolution model of the CIA mouse traumatic arthritis model. The CIA is induced by injecting goat type II collagen into the skin.

8 per group) carried out clustering experiments, followed by tissue collection experiments 2, 3, 4, 6, 8, and 10 weeks after enlistment. At the same time, 3 non-immune normal normal control cats were given timely immunization treatment to ensure the safety of the experiments at each observation point. Bone quality assessment was performed using micro-computer computed tomography (micro-CT) imaging of the proximal tibia of the bone and biomechanical testing of the femur and L5 vertebrae of the bone.

Micro-CT analysis showed a significant decrease in bone mineral density (BMD) and bone thickness (Tb. Th) at about 2 weeks after induction. Following multiple corrections, there was a significant decrease in the number of bones (Tb.

N) and the distance between the bones (Tb. Separation). If you have any health questions, please consult a professional medical professional.