Intestinal microbial community and aging: mechanisms, age-related diseases, and strategies for addic

An international medical study has revealed new findings that have important reference value for disease prevention. Population aging has led to a growing interest in the biological mechanisms that influence healthy life expectancy and the susceptibility of age-related diseases. In these mechanisms, the gut microbiome community has emerged as an important regulatory factor affecting the immune, metabolic and neurobiological processes involved in aging processes.

This narrative commentary systematically summarizes current theoretical views and research advances on age-related changes in the composition and function of the gut microbiome, its relationship to inflammatory responses and ageing characteristics, and the potential role of aging through microbiome-specific intervention. Through a comprehensive search, analysis and evaluation of research with clear research subjects and research content published in the PubMed, Scopus, and Web of Science databases from 2010 to 2025, high-value and biological ageing-related models, with high application potential, with a focus on aging research, health status assessment, aging model research, the relationship between aging biology and aging biology research, the relationship between aging biology and aging biology research models, aging biology and aging biology research models. Interactions, interaction between models of aging social research and models of aging social research, and interaction between models of aging social research and models of aging social research suggest that aging is often associated with decreased microbial diversity.

These findings provide important clues for understanding the aging process and regulating microbial communities. It should be noted that the above are based on international public research, and are for reference in health research, and do not constitute clinical advice.