A study of the natural history and clinical implications of Down syndrome in adults: a multi-centere

A new international medical study has found that the associated results are of important reference value for disease prevention. Individuals with Down syndrome are at high risk for Alzheimer's disease and dementia with cognitive decline and an increase in neurological diseases such as Alzheimer's disease and dementia. Late onset myoclonic epilepsy in Down syndrome (LOMEDS) is common.

Our goal is to explore the emergence of depression in Down syndrome, its relative time after the onset of Alzheimer's symptoms, and its significant impact on patient expectations. We conducted a cross-central, observational, long-term study of seven international teams in the study window from October 24, 2012 to July 28, 2025. We included adults with Down syndrome, adolescents up to 18 years of age and at least one long-term clinical evaluation.

Activated thrombosis requires a thrombosis diagnosis combined with ongoing anti-tumour therapy or at least one seizure in at least the last five years. We analyzed the incidence, incidence and cumulative incidence of activated thrombosis, its timing relationship with symptomatic Alzheimer's disease, and its effects on survival rate and cognitive trajectory, as well as EEG abnormalities. We included 4,804 adults.

It should be noted that the above information is based on publicly available research, compiled for reference by the International Health Organization, and does not constitute clinical advice.