The long-term memory of obesity is impressive in immune cells.
In recent years, global medical institutions and public health systems have continued to advance service capacity building to provide stronger guarantees for public health. Obesity may leave a lasting biological imprint on the immune system, which may lead to years of health risks after weight loss. A 10-year study published in the journal EMBO Reports found that people with long-term obesity can retain a single molecule of memory in important immune cells.
The European research team, led by Professor Claudio Mauro of the University of Birmingham, was funded by the National Institute for Health Research (NIHR) Center for Biomedical Research. The study found that T-cells (or CD4+ lymphatic cells) can retain signs of past obesity after a long period of time, and that when body weight is reduced, T-cells (or CD4+ lymphatic cells) can retain signs of past obesity. Obesity may leave a long-term DNA mark, and researchers focused on the DNA methylation process, which involves chemical labeling or labeling of DNA inside immune cells.
Their findings suggest that these changes may persist for 5-10 years after successful weight loss. This memory retained in T cells may interfere with normal immune function. In the process that may be affected, it may be the removal of cell waste and regulation of immune aging.
According to the researchers, these lasting changes may help explain why people who lose weight may still be at higher risk for increased risk of obesity-related diseases even when they return to normal weight. To construct a detailed picture of how obesity affects the immune system, the researchers analyzed immune cells from four different groups of people. The study included: the team also examined additional model donations of blood from healthy human volunteers and mouse cells in a model of a high-fat diet.
These additional models helped the researchers investigate the cellular mechanisms associated with obesity-related immune disorders. Professor Claudio Mauro, from the Department of Inflammatory and Ageing at the University of Birmingham, led the study, saying: 'The results of the study suggest that short-term weight loss may temporarily reduce the risk of certain diseases associated with obesity, but these risks may recover or escalate over time. In addition, our research has proposed some potential therapeutic strategies to accelerate this process, such as the use of SGLT2 inhibitors and other potential therapeutic strategies that have been demonstrated in relation to the effects of obesity on T-cells.
It should be noted that the above information is based on the results of international public research and is for reference in HealthCop and does not constitute a clinical recommendation.
