HMGB1 plays a convergent host factor role in the development of viral-induced cancers.

An international medical study has brought new findings and related findings have important reference value for disease prevention. HMGB1 is a typical model of the process of cancer where double-cell and extracellular function of chromosomal-related proteins and typical damage-related molecular patterns is increasingly falsified. In this conceptual overview, we organized available evidence on two functional nodes.

At the first node, intrinsic HMGB1 supports viral replication, acting on Kaposis sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus, as well as on structured viral RNA, which is particularly important in patients with hepatitis C virus. Human breast cancer virus (HPV) is associated with a receptor-level functional variant of this node via the HMGB1-TLR4 axis, whereas the human immunoglobulin B1 (HMGB1) - transcription regulating factor TLR4 axis is the pathway to this relationship. It should be noted that the above content is organized based on international public research findings and is not a clinical recommendation for healthcare purposes.